Understanding Kidney Disease

Hyperphosphatemia

Elevated phosphorus in the blood

Phosphorus is the second most prevalent mineral in the body and is fundamental to supporting life

Phosphorus gives cells the energy they need to function properly and provides important structural support for bones. While it may not be talked about as much, phosphorus is as important to maintaining a healthy body as other minerals, like calcium and iron. Phosphate is naturally found in protein-rich foods.

Phosphorus gives cells the energy they need to function properly and provides important structural support for bones. While it may not be talked about as much, phosphorus is as important to maintaining a healthy body as other minerals, like calcium and iron. Phosphate is naturally found in protein-rich foods.

A major role of the kidneys is to help your body maintain the right amount of phosphorus in your blood. As chronic kidney disease progresses, it becomes more difficult for the body to balance phosphorus levels and if too much is retained (it is called hyperphosphatemia).

Since high protein intake is recommended for people on dialysis, dietary restriction alone is typically insufficient for controlling phosphate levels. As a result, people with end stage renal disease (ESRD) on dialysis are frequently prescribed phosphate-binding medications to decrease their serum phosphorus levels.

Keep Reading

Hyperphosphatemia in CKD Quick Facts

  • With kidney disease, your kidneys cannot eliminate excess phosphorus
  • Almost all foods have phosphorus
  • Phosphate binders are tablets taken with food to help lower the amount of phosphorus absorbed by your body

Hyperphosphatemia in CKD Overview

Hyperphosphatemia is an abnormally high level of phosphate (phosphorus) in the blood. Hyperphosphatemia is a primary hallmark of chronic kidney disease, particularly in people with end stage renal disease (ESRD) or Stage 5D CKD. The majority of people with late-stage kidney disease who are on dialysis are hyperphosphatemic.

Clinical Practice Guidelines for Management of Serum Phosphorus in People on Dialysis

Kidney Disease: Improving Global Outcomes (KDIGO) and Kidney Disease: Outcomes Quality Initiative (KDOQI) guidelines include recommended target ranges of serum phosphorus in patients with advanced chronic kidney disease.

 

References:

  1. National Kidney Foundation. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis. 2003;42(4)(suppl 3):S1-201.
  2. Kidney Disease: Improving Global Outcomes (KDIGO) CKD–MBD Work Group. KDIGO 2017 clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD–MBD). Kidney Int. 2017;7(1):1–59.
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