About End Stage Renal Disease (ESRD) and Hyperphosphatemia

Chronic kidney disease (CKD) comes in five stages. End-stage renal disease (ESRD) is the term used to describe people with Stage 5 CKD who require dialysis or kidney transplantation to survive. In this stage, the kidneys have lost nearly all of their ability to function. ESRD represents the most severe stage of chronic kidney disease, as many metabolic factors, such as iron and phosphorus, are out of balance.

The majority of ESRD patients require chronic treatment with phosphate-binding medicines to lower and maintain serum phosphorus at acceptable levels to control a complication of ESRD known as hyperphosphatemia. Hyperphosphatemia is abnormally high blood phosphate which is caused by an increase in dietary phosphate intake. In addition, iron can be severely depleted in dialysis patients and they therefore are often treated with intravenous iron and other medications.

Approximately 450,000 ESRD patients require dialysis in the U.S., with the number projected to rise in the future.

Source: Coresh et al. JAMA. 2007;298(17):2038-2047